Journal of Pathology and Translational Medicine

Case Study

An Adult Case of Bartter Syndrome Type III Presenting with Proteinuria: Eun Jung Cha, Won Min Hwang, Sung-Ro Yun, Moon Hyang Park; J Pathol Transl Med. 2016;50(2):160-164. Published online January 11, 2016; DOI: https://doi.org/10.4132/jptm.2015.08.31

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Bartter syndrome (BS) I–IV is a rare autosomal recessive disorder affecting salt reabsorption in the thick ascending limb of the loop of Henle. This report highlights clinicopathological findings and genetic studies of classic BS in a 22-year-old female patient who presented with persistent mild proteinuria for 2 years. A renal biopsy demonstrated a mild to moderate increase in the mesangial cells and matrix of most glomeruli, along with marked juxtaglomerular cell hyperplasia. These findings suggested BS associated with mild IgA nephropathy. Focal tubular atrophy, interstitial fibrosis, and lymphocytic infiltration were also observed. A genetic study of the patient and her parents revealed a mutation of the CLCNKB genes. The patient was diagnosed with BS, type III. This case represents an atypical presentation of classic BS in an adult patient. Pathologic findings of renal biopsy combined with genetic analysis and clinicolaboratory findings are important in making an accurate diagnosis.

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World Journal of Pediatrics.2021; 17(1): 31. CrossRef
Association of Adult-Onset Bartter Syndrome With Undifferentiated Connective Tissue Disorder
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Brief Case Report

Dedifferentiated Endometrioid Adenocarcinoma of the Uterus: Highly Aggressive and Poor Prognostic Tumor: Shin Young Park, Moon Hyang Park, Hyoung Suk Ko, Eun Jung Cha, Jang Sihn Sohn, Un Suk Jung, Chul Jung Kim, Jin Suk Kim; Korean J Pathol. 2014;48(4):327-330. Published online August 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.4.327

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Treatment and outcomes in undifferentiated and dedifferentiated endometrial carcinoma
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Takako WAKAHARA, Sumiyo ADACHI, Kyota HANAMI, Takayoshi KOYASU, Yoshimitsu RYO, Kazunori FUGO, Kazuto YAMAZAKI
The Journal of the Japanese Society of Clinical Cytology.2022; 61(6): 385. CrossRef
Cytologic features of undifferentiated and dedifferentiated carcinomas of the endometrium
Amir‐Hossein Akbari, Lu Wang, Robert A. Soslow, Rajmohan Murali
Cancer Cytopathology.2021; 129(2): 121. CrossRef
Magnetic resonance imaging findings in 11 cases of dedifferentiated endometrial carcinoma of the uterus
Nao Kikkawa, Kimiteru Ito, Hiroshi Yoshida, Mayumi Kobayashi Kato, Yuko Kubo, Yasuyuki Onishi, Haruto Sugawara, Tomoyasu Kato, Masahiko Kusumoto
Japanese Journal of Radiology.2021; 39(5): 477. CrossRef
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
Rajmohan Murali, Ben Davidson, Oluwole Fadare, Joseph A. Carlson, Christopher P. Crum, C. Blake Gilks, Julie A. Irving, Anais Malpica, Xavier Matias-Guiu, W. Glenn McCluggage, Khush Mittal, Esther Oliva, Vinita Parkash, Joanne K. L. Rutgers, Paul N. Staat
International Journal of Gynecological Pathology.2019; 38(Supplement): S40. CrossRef
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Pooja Pandita, Xiyin Wang, Devin E. Jones, Kaitlyn Collins, Shannon M. Hawkins
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He Cai, Rong Zhou, Wanying Liang, Jianliu Wang
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Jiheun Han, Eun Young Ki, Sung Eun Rha, SooYoung Hur, Ahwon Lee
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Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma
Shinichi Harada, Keiki Nagaharu, Youichirou Baba, Tetsuya Murata, Toshiro Mizuno, Keiki Kawakami
Case Reports in Oncological Medicine.2017; 2017: 1. CrossRef
Ampullary carcinosarcoma with osteosarcomatous, small cell neuroendocrine carcinoma and conventional adenocarcinoma components; First report
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Case Study

Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study: Hyoungsuk Ko, Shin Young Park, Eun Jung Cha, Jang Sihn Sohn; Korean J Pathol. 2013;47(3):289-292. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.289

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Abstract PDF

Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.

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Intussusception of Heterotopic Gastric Mucosa in the Transverse Colon: A Rare Cause of Perforation and Bleeding
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Gastric heterotopia of the rectum
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Bleeding Gastric Heterotopia of Cecal Diverticulum in an Adolescent: A Case Report
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Gastric heterotopia of the rectum
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Polypoid Gastric Heterotopia of Colon
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Caroline Bsirini, Pratyusha Tirumanisetty, Joseph N. Dytoc, Diana Agostini-Vulaj, Christopher Steevens, Asad Ullah, Aaron R. Huber
International Journal of Surgical Pathology.2019; 27(2): 221. CrossRef
Perforation of Heterotopic Gastric Mucosa in ileal duplication in an adult: A case report
Vaanathi Paulvannan, Seshukumar Bylapudi, Mithun Kumar Ramesh Kumar, Mahesh Nachimuthu, Paulvannan Subramanian
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Louis J. Ligthelm, Belinda K. Bunn, Erich J. Raubenheimer, Willie F. P. van Heerden
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The outlet patch: gastric heterotopia of the colorectum and anus
Abul A S R Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam‐Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth A Montgomery
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Gastric heterotopia in the rectum. A rare cause of ectopic gastric tissue
George A. Salem, Javid Fazili, Tauseef Ali
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Gastric heterotopia in rectum: A literature review and its diagnostic pitfall
Peyman Dinarvand, Ashley A. Vareedayah, Nancy J Phillips, Christine Hachem, Jinping Lai
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Heterotopic gastric mucosa in the anus and rectum: first case report of endoscopic submucosal dissection and systematic review
Federico Iacopini, Takuji Gotoda, Walter Elisei, Patrizia Rigato, Fabrizio Montagnese, Yutaka Saito, Guido Costamagna, Giampaolo Iacopini
Gastroenterology Report.2016; 4(3): 196. CrossRef

Case Reports

Mature Teratoma in the Adrenal Gland.: Eun Jung Cha; Korean J Pathol. 2011;45:S98-S100.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S98

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Abstract PDF: A teratoma is a germ-cell tumor composed of tissue components representing derivatives of three germ layers. A teratoma in the region of adrenal gland is a rare retroperitoneal tumor. We now report a case of a primary adrenal teratoma. A 38-year-old woman presented with an incidentally detected adrenal mass. The computed tomography scan revealed a 9x8x7.5 cm fat density mass with calcification in the left adrenal gland. The surgically resected tumor was round and well circumscribed and the adrenal gland was present at the periphery of the tumor. The cut surface contained fat tissue and a hair containing cyst. Microscopically, the tumor consisted of adipose tissue, hair, skin appendage, nerve, muscle bundle and bone.

Bile Ductular Proliferation in the Gastric Wall after Gastric Ulcer Penetration into the Liver.: Eun Jung Cha; Korean J Pathol. 2011;45(4):434-436.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.434

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Abstract PDF: Liver penetration is one of the most serious complications of peptic ulcer diseases but is rarely encountered. A 57-year-old man was admitted to our hospital for further evaluation of a gastric malignancy. One month before admission, he was diagnosed with an adenocarcinoma by endoscopic biopsy at other hospital. A subtotal gastrectomy was performed to confirm malignancy and relieve the epigastric pain. Histologically, single glands were located between the ulcer base and attached liver tissue and stained positively for cytokeratin 19. The pathologic diagnosis was a gastric ulcer and bile ductular proliferation in the liver and gastric wall. Here, this report is the first Korean case of liver penetration of a gastric ulcer.

Actinomycosis of the Penile Shaft Coexisting with Fibrous Pseudotumor of the Testis.: Eun Jung Cha, Kyu Yun Jang, Ho Sung Park, Jong Kwan Park, Chang Seop Lee, Myoung Ja Chung, Woo Sung Moon, Dong Geun Lee, Myoung Jae Kang; Korean J Pathol. 2008;42(1):50-53.

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Abstract PDF: Here, we present an uncommon case of the penile shaft actinomycosis with coexisting fibrous pseudotumors of the testis. A 37-year-old, circumcised man presented with one penile and eight scrotal masses. The penile mass having a healed surface ulceration was located at the right side of the penile shaft. It was relatively circumscribed without a fibrous capsule. The cut surface showed a yellow-brown color with central focal necrosis. The scrotal tumors were circumscribed, whorled, white masses 0.3-2.0 cm in diameters, and were attached to the tunica vaginalis and tunica albuginea. Microscopically, the penile mass showed active inflammatory changes containing actinomyces displaying characteristic sulfur granules. Testicular masses were fibrous pseudotumors composed of bland spindle and stellate cells lying in dense collagenous stroma. Actinomycosis of the penis has been reported to occur at the corona of the uncircumcised penis associated with pilonidal sinus. The present case was not associated with pilonidal sinus and, unusually, displayed co-existence with fibrous pseudotumors of the testis.

Pseudometastasis in Sentinel Lymph Nodes with Cytokeratin Debris-containing Histiocytes in Breast Cancer Patient: A Case Report.: Keum Ha Choi, Eun Jung Cha, Ha Na Choi, Woo Sung Moon; Korean J Pathol. 2007;41(6):427-429.

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Abstract PDF: Immunohistochemical staining for cytokeratins can detect false negative nodes in patients with breast carcinoma. We report on a patient with breast carcinoma and pseudometastasis detected by immunohistochemical staining within a negative sentinel lymph node. A 66-year-old woman underwent a simple mastectomy and sentinel lymph node biopsy. Immunohistochemical staining of the sentinel nodes for cytokeratin in permanent sections showed cells with intense cytoplasmic staining in the subcapsular sinus. The cells were negative for epithelial membrane antigen staining, but positive for CD68. In combination with morphologic findings and immunohistochemistry, cytokeratin-positive cells were confirmed as histiocytes with phagocytized cytokeratin debris. Careful correlation with histology and additional IHC could help avoid a misinterpretation of this type of pseudometastasis.

Original Article

PPARgamma Ligand-Induced Decrease of in vivo Tumor Growth Accompanied by Increased Cytolytic Activity of Splenocytes.: Kyu Yun Jang, Ki Hoon Yu, Hak Yong Lee, Kyung Ryoul Kim, Ha Na Choi, Eun Jung Cha, Ho Sung Park, Woo Sung Moon, Myoung Jae Kang, Dong Geun Lee; Korean J Pathol. 2007;41(1):7-14.

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Abstract PDF: BACKGROUND
Recent studies have proposed the use of peroxisome proliferator activated receptor-gamma (PPARgamma) ligands as new chemotherapeutic agents for human malignant tumors. However the in vivo mechanism of PPARgamma ligands on cellular toxicity is not clear. Therefore we examined the anti-tumor effects of the PPARgamma ligand, rosiglitazone (ROS), in animal models.
METHODS
To evaluate the effect of RSO on splenocytes, an in vitro and in vivo study was performed. Cytolytic activity was measured by use of a 51Cr release assay. The splenic natural killer (NK) cell population and effector-target conjugation were measured by flow cytometric analysis.
RESULTS
In 9L glioma bearing rats, 30 mg/kg/d of ROS treatment induced a significant decrease of subcutaneous tumor growth accompanied by an increased cytolytic activity of splenocytes and of the splenic NKR-P1bright/CD3- NK cell population. In normal rats, systemic administration of ROS also increased the cytolytic activity of splenocytes, the splenic NK cell population, and effector-target conjugation. Moreover, we found that a concentration of 20micrometer ROS caused an increase in the cytolytic activity of splenocytes, and a concentration of 50micrometer ROS increased effector-target conjugation in vitro.
CONCLUSIONS
These results suggest that increased splenic cytolytic activity and NK cell population may contribute to the anti-tumor effects of PPARgamma ligands in vivo. However, the roles of NK cells in the PPARgamma ligand-induced anti-tumor activity should be further investigated.

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